[HTML][HTML] Deficiency in the membrane protein Tmbim3a/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish
K Chen, X Li, G Song, T Zhou, Y Long, Q Li… - Journal of Biological …, 2019 - ASBMB
Most members of the family of proteins containing a transmembrane BAX inhibitor motif
(TMBIM) have anti-apoptotic activity, but their in vivo functions and intracellular mechanisms
remain obscure. Here, we report that zebrafish Tmbim3a/Grinaa functions in the prevention
of cold-induced endoplasmic reticulum (ER) stress and apoptosis. Using a gene-trapping
approach, we obtained a mutant zebrafish line in which the expression of the
tmbim3a/grinaa gene is disrupted by a Tol2 transposon insertion. Homozygous …
(TMBIM) have anti-apoptotic activity, but their in vivo functions and intracellular mechanisms
remain obscure. Here, we report that zebrafish Tmbim3a/Grinaa functions in the prevention
of cold-induced endoplasmic reticulum (ER) stress and apoptosis. Using a gene-trapping
approach, we obtained a mutant zebrafish line in which the expression of the
tmbim3a/grinaa gene is disrupted by a Tol2 transposon insertion. Homozygous …
